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НОВОЕ О ВАКЦИНАХ

ПРАВИЛЬНОЕ ПИТАНИЕ
ПОЛЬЗА И ВРЕД ВИТАМИНОВ

Лечение позиционного головокружения (вертиго)

Как быстро заснуть

Короткие советы на каждый день

Живите сегодня, потому что вчера уже нет, а завтра может и не наступить
Если виноваты – сразу скажите об этом и не ищите себе оправдания
У каждого своя правда, и она часто не совпадает с вашей
Истина едина, заблуждение многолико, а правда у каждого своя
Проблемы человека находятся только в его голове
Всегда помните, что другой жизни у вас не будет
Помните, что вы никому ничего не должны
Помните, что никто вам ничего не должен
В жизни всегда рассчитывайте только на себя
Верьте не обещаниям, а своим ощущениям
Знайте, что сегодняшний день – это лучший день вашей жизни

2022

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy doi:10.1038/s43587-022-00278-w

The impact of Rhodiola rosea on biomarkers of diabetes, inflammation, and microbiota in a leptin receptor-knockout mouse model doi:10.1038/s41598-022-14241-7

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation doi:10.1016/j.cell.2022.07.003

Nitric oxide signaling in health and disease doi:10.1016/j.cell.2022.06.010

Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis doi:10.1038/s41467-022-31890-4

Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease doi:10.1016/j.stem.2022.06.007

High‐dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression doi:10.1002/hup.2852

Effects of Cuisine-Based Chinese Heart-Healthy Diet in Lowering Blood Pressure Among Adults in China doi:10.1161/CIRCULATIONAHA.122.059045

Associations Between Prenatal Urinary Biomarkers of Phthalate Exposure and Preterm Birth doi:10.1001/jamapediatrics.2022.2252

Delineating a serotonin 1B receptor circuit for appetite suppression in mice doi:10.1084/jem.20212307

Что же Петр Чумаков сказал про SARS-CoV-2 и «омикрон»?

Дефицита кадров нет, платить больше - не нужно

Прогетерон разрушается 20-альфа гидроксистероид дегидрогеназой doi:10.1038/s41586-022-04828-5

The molecular impact of life in an indoor environment doi:10.1126/sciadv.abn8016

Risk of Alzheimer’s Disease Following Influenza Vaccination: A Claims-Based Cohort Study Using Propensity Score Matching doi:10.3233/JAD-220361

Subventricular zone adult mouse neural stem cells require insulin receptor for self-renewal doi:10.1016/j.stemcr.2022.04.007

Researchers identify possible new target to treat newborns suffering from lack of oxygen or blood flow in the brain (Neonatal hypoxia ischemia redistributes L1 cell adhesion molecule into rat cerebellar lipid rafts) doi:10.1038/s41390-022-01974-4

The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62 doi:10.1016/j.celrep.2022.110792

FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice doi:10.1038/s41467-022-29499-8

Association of egg consumption, metabolic markers, and risk of cardiovascular diseases doi:10.7554/eLife.72909

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis doi:10.1126/sciadv.abm5371

Nutrition, longevity and disease: From molecular mechanisms to interventions doi:10.1016/j.cell.2022.04.002

Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy doi:10.1038/s41467-022-29752-0

Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control doi:10.1002/jcsm.12982

Glutamine promotes escape from therapy-induced senescence in tumor cells doi:10.18632/aging.203495

Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin doi:10.1084/jem.20211906

Activation of the Zinc-sensing receptor GPR39 promotes T cell reconstitution after hematopoietic cell transplant in mice doi:10.1182/blood.2021013950

The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease doi:10.1126/scitranslmed.abl7634

Discovery could pave way for new lung treatment: Study finds stimulation of new family of proteins prevents fluid from entering lung (Agonists for Bitter Taste Receptors T2R10 and T2R38 Attenuate LPS-Induced Permeability of the Pulmonary Endothelium in vitro) doi:10.3389/fphys.2022.794370

A gut-derived metabolite alters brain activity and anxiety behaviour in mice doi:10.1038/s41586-022-04396-8

RNA profiles reveal signatures of future health and disease in pregnancy doi:10.1038/s41586-021-04249-w

Bacterial Genotoxin Accelerates Transient Infection–Driven Murine Colon Tumorigenesis doi:10.1158/2159-8290.CD-21-0912

Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production doi:10.1126/science.abg3067

Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses doi:10.1128/mbio.03226-21

2021

Weeklong improved colour contrasts sensitivity after single 670 nm exposures associated with enhanced mitochondrial function doi:10.1038/s41598-021-02311-1

Central Insulin Modulates Dopamine Signaling in the Human Striatum doi:10.1210/clinem/dgab410

Z-form extracellular DNA is a structural component of the bacterial biofilm matrix doi:10.1016/j.cell.2021.10.010

Antibiotics can be first-line therapy for uncomplicated appendicitis cases doi:10.1001/jama.2021.20502

Molecular profiling of individual FDA-approved clinical drugs identifies modulators of nonsense-mediated mRNA decay doi:10.1016/j.omtn.2021.12.003

Microbial exposure during early human development primes fetal immune cells doi:10.1016/j.cell.2021.04.039

Regulation of the one carbon folate cycle as a shared metabolic signature of longevity doi:10.1038/s41467-021-23856-9

Evidence based guidelines for the treatment of Helicobacter pylori infection in Korea 2020 doi:10.3904/kjim.2020.701

The connexin 43 carboxyl terminal mimetic peptide alphaCT1 prompts differentiation of a collagen scar matrix in humans resembling unwounded skin doi:10.1096/fj.202001881R

Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice doi:10.1111/acel.13285

Antiallergic drug desloratadine as a selective antagonist of 5HT2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction doi:10.1111/acel.13286

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle doi:10.1016/j.celrep.2020.108660

Metoclopramide treatment blocks CD93-signaling-mediated self-renewal of chronic myeloid leukemia stem cells doi:10.1016/j.celrep.2020.108663

Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength doi:10.1126/science.abc8059

Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling doi:10.1111/acel.13261

Metabolic dysfunction in human skin: Restoration of mitochondrial integrity and metabolic output by nicotinamide (niacinamide) in primary dermal fibroblasts from older aged donors doi:10.1111/acel.13248

Inceptor counteracts insulin signalling in beta-cells to control glycaemia doi:10.1038/s41586-021-03225-8

Restoring metabolism of myeloid cells reverses cognitive decline in ageing doi:10.1038/s41586-020-03160-0

Once-Weekly Semaglutide in Adults with Overweight or Obesity (Gamechanger for treating obesity cuts body weight by 20 percent) doi:10.1056/NEJMoa2032183

Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis doi:10.1016/j.cell.2021.03.002

Dopamine prevents ultraviolet B-induced development and progression of premalignant cutaneous lesions through its D2 receptors doi:10.1158/1940-6207.CAPR-21-0052

Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence doi:10.1038/s41586-021-03417-2

A selective p53 activator and anticancer agent to improve colorectal cancer therapy doi:10.1016/j.celrep.2021.108982

Pharmacological inhibition of protein tyrosine phosphatase 1B (Тродусквемин, Trodusquemine) protects against atherosclerotic plaque formation in the LDLR -/- mouse model of atherosclerosis doi:10.1042/cs20171066

Селективные антагонисты аденозинового рецептора a2a для изготовления лекарственного средства для лечения фибрилляции предсердий
Обнаружено, что аденозиновый рецептор А2A предсердных кардиомиоцитов участвует в патологических механизмах, лежащих в основе фибрилляции предсердий. Преимущество применения селективных антагонистов А2A (ZM214385, Н-89, SCH58261) относительно других агентов состоит в том, что антагонисты A2A специфически направлены на пациентов с фибрилляцией предсердий: снижают повышенную частоту волн кальция при их фибрилляции, т.е. участвуют в электрическом ремоделировании предсердия в состоянии фибрилляции

Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing doi:10.1038/s41380-021-01208-9

Airway basal stem cells reutilize the embryonic proliferation regulator, Tgf-beta-Id2 axis, for tissue regeneration doi:10.1016/j.devcel.2021.05.016

Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation doi:10.1016/j.celrep.2021.109411

Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice doi:10.7554/eLife.67604

Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells in diabetes doi:10.1016/j.celrep.2021.109490

A noncoding RNA modulator potentiates phenylalanine metabolism in mice doi:10.1126/science.aba4991

Phase II Open-Label, Single-Arm Trial to Investigate the Efficacy and Safety of Topical Remetinostat Gel in Patients with Basal Cell Carcinoma doi:10.1158/1078-0432.CCR-21-0560

Disruptor of telomeric silencing 1-like promotes ovarian cancer tumor growth by stimulating pro-tumorigenic metabolic pathways and blocking apoptosis doi:10.1038/s41389-021-00339-6

TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor doi:10.1016/j.chembiol.2021.07.014

Anti-ageing effects of protein restriction unpacked DOI: 10.1038/d41586-020-03662-x

Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice DOI: 10.1038/s43587-020-00006-2

A Single-Cell Transcriptomic Atlas of Human Skin Aging DOI: 10.1016/j.devcel.2020.11.002

Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth DOI: 10.1158/1535-7163.MCT-20-0480

Restoring metabolism of myeloid cells reverses cognitive decline in ageing DOI: 10.1038/s41586-020-03160-0

2020

D-serine mitigates cell loss associated with temporal lobe epilepsy DOI: 10.1038/s41467-020-18757-2

Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome doi:10.1038/s41514-020-0046-6

ATF4 links ER stress with reticulophagy in glioblastoma cells DOI: 10.1080/15548627.2020.1827780

Identification and Characterization of Novel Bronchodilator Agonists Acting at Human Airway Smooth Muscle Cell TAS2R5 DOI: 10.1021/acsptsci.0c00127

NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle DOI: 10.1016/j.celrep.2020.108660

NAD Repletion Rescues Female Fertility during Reproductive Aging DOI: 10.1016/j.celrep.2020.01.058

Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials DOI: 10.1136/jnnp-2019-320912

Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury DOI: 10.1172/JCI130391

Cell aging and cellular senescence in skin aging — Recent advances in fibroblast and keratinocyte biology DOI: 10.1016/j.exger.2019.110780

The guidance receptor plexin D1 is a mechanosensor in endothelial cells DOI: 10.1038/s41586-020-1979-4

Correlation between Oral Health and Systemic Inflammation (COHESION): A Randomized Pilot Follow Up Trial of a Plaque Identifying Toothpaste DOI: 10.1016/j.amjmed.2020.01.023

Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension DOI: 10.1161/HYPERTENSIONAHA.119.14294

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence DOI: 10.1101/gad.331272.119

Mechanical regulation of glycolysis via cytoskeleton architecture. Nature, 2020, 578, 621–626. DOI: 10.1038/s41586-020-1998-1

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease DOI: 10.1016/j.cmet.2020.02.004

Gut enzyme IAP found to prevent aging and frailty in animal models ScienceDaily, 26 March 2020

Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme - A plausible missing link for their association with incidence of dementia DOI: 10.1002/alz.12113

Glutamine Metabolism Controls Chondrocyte Identity and Function DOI: 10.1016/j.devcel.2020.05.001

Vitamin B3 revitalizes energy metabolism in muscle disease Niacin Cures Systemic NAD Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy DOI: 10.1016/j.cmet.2020.04.008

Notch signalling drives synovial fibroblast identity and arthritis pathology DOI: 10.1038/s41586-020-2222-z

RhoJ Regulates alpha5beta1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis DOI: 10.1016/j.cub.2020.03.042

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan DOI: 10.18632/aging.103534

Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity DOI: 10.1016/j.cmet.2020.06.006

Oxytocin reverses Abeta-induced impairment of hippocampal synaptic plasticity in mice DOI: 10.1016/j.bbrc.2020.04.046

Cxcl9l and Cxcr3.2 regulate recruitment of osteoclast progenitors to bone matrix in a medaka osteoporosis model DOI: 10.1073/pnas.2006093117

PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle DOI: 10.1016/j.cmet.2020.06.017

New type of taste cell discovered in taste buds A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli DOI:10.1371/journal.pgen.1008925

2019

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL DOI: 10.1038/s41586-019-1608-2

Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways DOI: 10.1016/j.cell.2019.10.027

Selective effects of acute low-grade inflammation on human visual attention DOI: 10.1016/j.neuroimage.2019.116098

Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial DOI: 10.1007/s11357-019-00113-y

The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts DOI: 10.18632/oncotarget.27268

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence DOI: 10.1038/s41467-019-13314-y

Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity DOI: 10.1016/j.celrep.2019.06.078

Mevastatin in development could help heal chronic skin wounds. Croft A P et al. Distinct fibroblast subsets drive inflammation and damage in arthritis DOI: 10.1038/s41586-019-1263-7

Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection DOI: 10.1038/s41422-019-0153-8

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains DOI: 10.1038/s41586-019-1088-4

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity DOI: 10.1016/j.devcel.2018.12.002

PDGFR-beta Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration DOI: 10.1016/j.celrep.2019.06.065

Stimulation of Hair Growth by Small Molecules that Activate Autophagy DOI: 10.1016/j.celrep.2019.05.070

2018

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth DOI: 10.1038/s41586-018-0387-5

Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations DOI: 10.1016/j.cell.2018.06.005

Verapamil and beta cell function in adults with recent-onset type 1 diabetes DOI: 10.1038/s41591-018-0089-4

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR DOI: 10.1016/j.cell.2018.05.009

Catalytic activation of β-arrestin by GPCRs DOI: 10.1038/s41586-018-0079-1

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors DOI: 10.1038/s41586-018-0762-2

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults DOI: 10.1038/s41467-018-03421-7

2017

Regulation of the Hippo Pathway Transcription Factor TEAD DOI: 10.1016/j.tibs.2017.09.003

Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis DOI: 10.1172/jci.insight.97152

R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature DOI: 10.1038/s41467-017-01865-x

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function DOI: 10.1038/s41467-017-01783-y

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy DOI: 10.1038/nature25013

2015

Лечение каткракты без операции - ланостерол

Новое лекарство от малярии

2014

Комбинация мекиниста и тафинлара для терапии метастатической меланомы - существенный прогресс в лечении

Полицейский преградил дорогу грузовику для предотвращения ДТП с автобусом с детьми